Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.

Brigger, Daniel; Riether, Carsten; van Brummelen, Robin; Mosher, Kira I; Shiu, Alicia; Ding, Zhaoqing; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal; Yousef, Hanadie; Castellano, Joseph M; Storni, Federico; Graff-Radford, Neill; Britschgi, Markus; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Moullan, Norman; Hofstetter, Wilhelm; Leib, Stephen L.; ... (2020). Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature metabolism, 2(8), pp. 688-702. Springer Nature 10.1038/s42255-020-0228-3

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Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs remains unknown. Here, we show that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. We find that exposure to a young systemic environment partially restores ATE distribution in aged parabionts and reduces adipose tissue inflammation. Approaches to restore ATE distribution using adoptive transfer of eosinophils from young mice into aged recipients proved sufficient to dampen age-related local and systemic low-grade inflammation. Importantly, restoration of a youthful systemic milieu by means of eosinophil transfers resulted in systemic rejuvenation of the aged host, manifesting in improved physical and immune fitness that was partially mediated by eosinophil-derived IL-4. Together, these findings support a critical function of adipose tissue as a source of pro-ageing factors and uncover a new role of eosinophils in promoting healthy ageing by sustaining adipose tissue homeostasis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Brigger, Daniel; Riether, Carsten; van Brummelen, Rosa Robin; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal Martin; Storni, Federico Lorenzo; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Hofstetter, Wilhelm; Leib, Stephen; Villiger, Peter; Noti, Mario and Eggel, Alexander

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2522-5812

Publisher:

Springer Nature

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

31 Aug 2020 17:15

Last Modified:

22 Dec 2020 15:51

Publisher DOI:

10.1038/s42255-020-0228-3

PubMed ID:

32694825

BORIS DOI:

10.7892/boris.146082

URI:

https://boris.unibe.ch/id/eprint/146082

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