Snyder, Michael P; Gingeras, Thomas R; Moore, Jill E; Weng, Zhiping; Gerstein, Mark B; Ren, Bing; Hardison, Ross C; Stamatoyannopoulos, John A; Graveley, Brenton R; Feingold, Elise A; Pazin, Michael J; Pagan, Michael; Gilchrist, Daniel A; Hitz, Benjamin C; Cherry, J Michael; Bernstein, Bradley E; Mendenhall, Eric M; Zerbino, Daniel R; Frankish, Adam; Flicek, Paul; ... (2020). Perspectives on ENCODE. Nature, 583(7818), pp. 693-698. 10.1038/s41586-020-2449-8
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The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1476-4687 |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
28 Aug 2020 15:06 |
Last Modified: |
12 Mar 2021 06:57 |
Publisher DOI: |
10.1038/s41586-020-2449-8 |
PubMed ID: |
32728248 |
Additional Information: |
Collaborator ENCODE Project Consortium: Johnson, Rory |
BORIS DOI: |
10.7892/boris.146108 |
URI: |
https://boris.unibe.ch/id/eprint/146108 |
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