Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients

Dietmann, Anelia; Horn, Michael P.; Schinkelshoek, Mink S.; Fronczek, Rolf; Salmen, Anke; Bargiotas, Panagiotis; Lammers, Gert J.; Khatami, Ramin; Bassetti, Claudio L.A. (2020). Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients. Sleep medicine, 75, pp. 188-191. Elsevier 10.1016/j.sleep.2020.08.001

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Narcolepsy with cataplexy (NT1) is a chronic hypothalamic disorder with a presumed immune-mediated etiology leading to a loss of hypocretin neurons. Previous studies reported conflicting results in terms of presence of auto-antibodies involved in narcolepsy pathophysiology. A total of 86 patients with primary/idiopathic narcolepsy (74 NT1, 12 NT2) and 23 control patients with excessive daytime sleepiness due to other causes were tested for the presence of a wide range of anti-neuronal antibodies in both serum and cerebrospinal fluid (CSF). Anti-neuronal antibodies were rarely found in patients with narcolepsy (n = 2) and in controls (n = 1). Our results are in line with previous reports. We can therefore support the current evidence, that conventional anti-neuronal antibodies are not routinely detected during the workup of NT1 and other CDH patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Dietmann, Anelia; Horn, Michael; Salmen, Anke; Bargiotas, Panagiotis; Khatami, Ramin and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1389-9457

Publisher:

Elsevier

Language:

English

Submitter:

Karin Balmer

Date Deposited:

02 Sep 2020 11:20

Last Modified:

02 Sep 2020 11:25

Publisher DOI:

10.1016/j.sleep.2020.08.001

PubMed ID:

32858359

BORIS DOI:

10.7892/boris.146174

URI:

https://boris.unibe.ch/id/eprint/146174

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