Gender differences in first episode psychotic mania

Cotton, Sue M.; Lambert, Martin; Berk, Michael; Schimmelmann, Benno G.; Butselaar, Felicity J.; McGorry, Patrick D.; Conus, Philippe (2013). Gender differences in first episode psychotic mania. BMC psychiatry, 13, p. 82. London: BioMed Central 10.1186/1471-244X-13-82

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Background The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients. Methods Medical file audit assessment of 118 (male = 71; female = 47) patients with FEPM aged 15 to 29 years was undertaken on clinical and functional measures. Results Males with FEPM had increased likelihood of substance use (OR = 13.41, p < .001) and forensic issues (OR = 4.71, p = .008), whereas females were more likely to have history of sexual abuse trauma (OR = 7.12, p = .001). At service entry, males were more likely to be using substances, especially cannabis (OR = 2.15, p = .047), had more severe illness (OR = 1.72, p = .037), and poorer functioning (OR = 0.96, p = .045). During treatment males were more likely to decrease substance use (OR = 5.34, p = .008) and were more likely to be living with family (OR = 4.30, p = .009). There were no gender differences in age of onset, psychopathology or functioning at discharge. Conclusions Clinically meaningful gender differences in FEPM were driven by risk factors possibly associated with poor outcome. For males, substance use might be associated with poorer clinical presentation and functioning. In females with FEPM, the impact of sexual trauma on illness course warrants further consideration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Schimmelmann, Benno Karl Edgar

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1471-244X

Publisher:

BioMed Central

Language:

English

Submitter:

Myriam Pyrlik

Date Deposited:

04 Oct 2013 14:36

Last Modified:

24 Dec 2014 19:46

Publisher DOI:

10.1186/1471-244X-13-82

PubMed ID:

23497439

Web of Science ID:

000316272500001

Uncontrolled Keywords:

Gender, Mania, Psychosis, Bipolar disorder

BORIS DOI:

10.7892/boris.14631

URI:

https://boris.unibe.ch/id/eprint/14631 (FactScience: 221704)

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