Simplifying LR-HSQC spectra using a triple-quantum filter: The LR-HTQC experiment

Bigler, Peter; Furrer, Julien (2021). Simplifying LR-HSQC spectra using a triple-quantum filter: The LR-HTQC experiment. Magnetic resonance in chemistry, 59(1), pp. 52-60. Wiley Heyden 10.1002/mrc.5078

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Long‐range heteronuclear single quantum correlation (LR‐HSQC) experiments may be applied for detecting long‐range correlations but suffer from two disadvantages, common to all heteronuclear long‐range correlation experiments: (i) The information density in LR‐HSQC spectra may be too high to be used directly without “filtering out” shorter range correlations, and (ii) often, substantial differences in intensity among cross peaks exist, potentially hampering the visualization of weak, often crucial cross peaks. In this contribution, we propose a modified LR‐HSQC experiment, the LR‐HTQC experiment (Long‐Range Heteronuclear Triple Quantum Correlation) that partially solves the problems aforementioned. We show theoretically and experimentally that the LR‐HTQC experiment removes the intense cross peaks of CH spin pairs, substantially reduces the medium intensity of cross peaks originating from CHH' spin systems, whereas the typically weak intensity of cross peaks of CHH'H″ and C(H)n, n > 3 spin systems is less affected. Consequently, the LR‐HTQC experiment affords simplified long‐range heteronuclear shift correlation spectra and scales down large intensity differences among different types of cross peaks, although a certain general reduction of signal intensities has to be accepted.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
08 Faculty of Science > Other Institutions > Emeriti, Faculty of Science

UniBE Contributor:

Bigler, Peter, Furrer, Julien


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry




Wiley Heyden




Julien Henri Lucien Furrer

Date Deposited:

03 Sep 2020 16:36

Last Modified:

05 Dec 2022 15:40

Publisher DOI:





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