A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement.

Eslam, Mohammed; Newsome, Philip N; Sarin, Shiv K; Anstee, Quentin M; Targher, Giovanni; Romero-Gomez, Manuel; Zelber-Sagi, Shira; Wai-Sun Wong, Vincent; Dufour, Jean-François; Schattenberg, Jörn M; Kawaguchi, Takumi; Arrese, Marco; Valenti, Luca; Shiha, Gamal; Tiribelli, Claudio; Yki-Järvinen, Hannele; Fan, Jian-Gao; Grønbæk, Henning; Yilmaz, Yusuf; Cortez-Pinto, Helena; ... (2020). A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. Journal of hepatology, 73(1), pp. 202-209. Elsevier 10.1016/j.jhep.2020.03.039

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The exclusion of other chronic liver diseases including "excess" alcohol intake has until now been necessary to establish a diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD). However, given our current understanding of the pathogenesis of MAFLD and its rising prevalence, "positive criteria" to diagnose the disease are required. In this work, a panel of international experts from 22 countries propose a new definition for the diagnosis of MAFLD that is both comprehensive and simple, and is independent of other liver diseases. The criteria are based on evidence of hepatic steatosis, in addition to one of the following three criteria, namely overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation. We propose that disease assessment and stratification of severity should extend beyond a simple dichotomous classification to steatohepatitis vs. non-steatohepatitis. The group also suggests a set of criteria to define MAFLD-associated cirrhosis and proposes a conceptual framework to consider other causes of fatty liver disease. Finally, we bring clarity to the distinction between diagnostic criteria and inclusion criteria for research studies and clinical trials. Reaching consensus on the criteria for MAFLD will help unify the terminology (e.g. for ICD-coding), enhance the legitimacy of clinical practice and clinical trials, improve clinical care and move the clinical and scientific field of liver research forward.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1600-0641

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

08 Dec 2020 08:52

Last Modified:

08 Dec 2020 08:52

Publisher DOI:

10.1016/j.jhep.2020.03.039

PubMed ID:

32278004

Uncontrolled Keywords:

Cirrhosis Diabetes Diagnostic criteria MAFLD Metabolic NAFLD Obesity Steatohepatitis

BORIS DOI:

10.7892/boris.146467

URI:

https://boris.unibe.ch/id/eprint/146467

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