Zohdi, Hamoon; Scholkmann, Felix; Wolf, Ursula (2020). Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day. Neurophotonics, 7(2), 025006. SPIE 10.1117/1.NPh.7.2.025006
|
Text
025006_1.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-handed subjects with the systemic physiology augmented functional near infrared spectroscopy (SPA-fNIRS) approach. Approach: Subjects were measured 2 to 4 times on different days resulting in an unprecedented number of 518 single measurements of the absolute values of tissue oxygen saturation ( ) and total hemoglobin concentration ([tHb]) of the right and left PFC. Measurements were performed with frequency-domain functional near-infrared spectroscopy. In addition, the cardiorespiratory parameters were measured simultaneously. Results: We found that (i) subjects showed an FCOA (higher on the right PFC), but not for tHb; (ii) intrasubject variability was excellent for both and tHb, and fair for FCOA; (iii) correlated significantly with blood concentration, [tHb] with heart rate, respiration rate (RR), and the pulse-respiration quotient (PRQ), and FCOA with RR and PRQ; (iv) FCOA and were dependent on season and time of day, respectively; (v) FCOA was negatively correlated with the room temperature; and (vi) and tHb were not correlated with the subjects mood but with their chronotype, whereas FCOA was not dependent on the chronotype. Conclusion: Our study demonstrates that FCOA is real, and it provides unique insights into this remarkable phenomenon.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM) |
UniBE Contributor: |
Zohdi, Hamoon, Scholkmann, Felix Vishnu, Wolf, Ursula |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2329-423X |
Publisher: |
SPIE |
Language: |
English |
Submitter: |
Svenja Hänni |
Date Deposited: |
17 Sep 2020 08:42 |
Last Modified: |
02 Mar 2023 23:33 |
Publisher DOI: |
10.1117/1.NPh.7.2.025006 |
PubMed ID: |
32607390 |
Uncontrolled Keywords: |
functional near-infrared spectroscopy prefrontal cortex right–left asymmetry systemic physiology tissue oxygenation |
BORIS DOI: |
10.7892/boris.146518 |
URI: |
https://boris.unibe.ch/id/eprint/146518 |
Actions (login required)
 |
Edit item |