Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day.

Zohdi, Hamoon; Scholkmann, Felix; Wolf, Ursula (2020). Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day. Neurophotonics, 7(2), 025006. SPIE 10.1117/1.NPh.7.2.025006

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Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-handed subjects with the systemic physiology augmented functional near infrared spectroscopy (SPA-fNIRS) approach. Approach: Subjects were measured 2 to 4 times on different days resulting in an unprecedented number of 518 single measurements of the absolute values of tissue oxygen saturation ( ) and total hemoglobin concentration ([tHb]) of the right and left PFC. Measurements were performed with frequency-domain functional near-infrared spectroscopy. In addition, the cardiorespiratory parameters were measured simultaneously. Results: We found that (i) subjects showed an FCOA (higher on the right PFC), but not for tHb; (ii) intrasubject variability was excellent for both and tHb, and fair for FCOA; (iii)  correlated significantly with blood concentration, [tHb] with heart rate, respiration rate (RR), and the pulse-respiration quotient (PRQ), and FCOA with RR and PRQ; (iv) FCOA and were dependent on season and time of day, respectively; (v) FCOA was negatively correlated with the room temperature; and (vi)  and tHb were not correlated with the subjects mood but with their chronotype, whereas FCOA was not dependent on the chronotype. Conclusion: Our study demonstrates that FCOA is real, and it provides unique insights into this remarkable phenomenon.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Zohdi, Hamoon, Scholkmann, Felix Vishnu, Wolf, Ursula


600 Technology > 610 Medicine & health








Svenja Hänni

Date Deposited:

17 Sep 2020 08:42

Last Modified:

02 Mar 2023 23:33

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

functional near-infrared spectroscopy prefrontal cortex right–left asymmetry systemic physiology tissue oxygenation




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