Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD)

Bergmann-Hug, Katrin; Fricker, Michael; Hausmann, Oliver; Helbling, Arthur; Jörg, Lukas (2020). Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD). PLoS ONE, 15(9), e0238740. Public Library of Science 10.1371/journal.pone.0238740

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Sensitization to Hymenoptera venom in patients without a history of systemic allergic reactions to Hymenoptera stings is frequently found and can be due to the presence of specific IgE to cross-reactive carbohydrate determinants (CCD). This study investigates 105 pollen allergic subjects for the presence of specific IgE to honeybee or wasp venom, pollen, the MUXF3 carbohydrate epitope from bromelain and recombinant Hymenoptera venom components. In addition, in a subgroup of patients (n = 10) a basophil activation test (BAT) using bee and wasp venom was performed. Specific IgE to Hymenoptera venom was detected in 45.7% of the pollen allergic subjects and in 26.7% of the non-atopic controls, both without a history of systemic allergic reactions to Hymenoptera stings. The high sensitization rate in atopic patients could partially be explained by cross-sensitization between pollen and Hymenoptera venom due to specific IgE to CCDs. In our study population, only 20% showed a sensitization to CCDs. Primary sensitization due to sting exposure, high total IgE values or unspecific binding and detection of low affinity antibodies in the test procedure could be reasons. Thus, determination of specific IgE to Hymenoptera venom in patients without a history of systemic allergic reactions as screening test is not recommended.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Fricker, Michael; Hausmann, Oliver; Helbling, Arthur and Jörg, Lukas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Lukas Jörg

Date Deposited:

10 Dec 2020 14:19

Last Modified:

18 Jan 2022 12:26

Publisher DOI:

10.1371/journal.pone.0238740

PubMed ID:

32898145

Uncontrolled Keywords:

cross-reactive carbohydrate determinants (CCD); Hymenoptera venom; pollen allergy; sensitization; specific IgE; MUXF3; basophil activation test; bee; wasp; venom

BORIS DOI:

10.7892/boris.146594

URI:

https://boris.unibe.ch/id/eprint/146594

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