Sistonen, Johanna; Smith, Chingying; Fu, Yung-Kang; Largiadèr, Carlo R (2012). A new DPYD genotyping assay for improving the safety of 5-fluorouracil therapy. Clinica chimica acta, 414, pp. 109-111. Amsterdam: Elsevier 10.1016/j.cca.2012.08.015
Full text not available from this repository.Chemotherapeutic use of 5-fluorouracil (5FU) is compromised by 10-20% of patients developing severe toxicity. Recently described genetic variation in dihydropyrimidine dehydrogenase (DPYD) has been shown to be a major predictor of 5FU toxicity. Here, we describe a new genotyping assay for routine clinical use that covers all the major DPYD risk variants.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Sistonen, Johanna, Largiadèr, Carlo Rodolfo |
ISSN: |
0009-8981 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:36 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1016/j.cca.2012.08.015 |
PubMed ID: |
22935545 |
Web of Science ID: |
000312685400023 |
URI: |
https://boris.unibe.ch/id/eprint/14663 (FactScience: 221745) |
Actions (login required)
 |
Edit item |