Functional topography of the thalamo-cortical system during development and its relation to cognition.

Steiner, Leonie; Federspiel, Andrea; Slavova, Nedelina; Wiest, Roland; Grunt, Sebastian; Steinlin, Maja; Everts, Regula (2020). Functional topography of the thalamo-cortical system during development and its relation to cognition. (In Press). NeuroImage, 223, p. 117361. Elsevier 10.1016/j.neuroimage.2020.117361

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The thalamus has complex connections with the cortex and is involved in various cognitive processes. However, little is known about the age-related changes of thalamo-cortical connections and their relation to cognitive abilities. The present study analysed resting-state functional connectivity between the thalamus and nine cortical functional networks (default mode network (DMN), posterior DMN, left/right executive, dorsal attention, salience, motor, visual and auditory network) in a healthy human sample (N=95, aged 5 to 25 years). Cognitive abilities, including processing speed, selective attention, and cognitive flexibility were assessed using neuropsychological tests. All nine cortical resting state networks showed functional connections to the thalamus at rest, with no effect for sex (p > 0.05). For the motor, visual, auditory, DMN, posterior DMN, salience and dorsal attention network, we found mainly bilateral thalamic projections in the mediodorsal nucleus, pulvinar and in nuclei of the lateral group. For the right and left lateralized executive network, corresponding lateralized thalamic projections were found. Thalamo-cortical connectivity strength showed significant age-related decreases from distinct sub-nuclei of the thalamus to different cortical networks including the visual, DMN, salience and dorsal attention network. Further, connectivity strength of thalamo-cortical networks was associated with cognitive abilities, including processing speed, selective attention and cognitive flexibility. Better cognitive abilities were associated with increased thalamo-cortical connectivity in the pulvinar, mediodorsal, intralaminar, and nuclei from the lateral group. Alterations in the integrity of the thalamo-cortical system seem to be crucial for the development of cognitive abilities during brain maturation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Steiner, Leonie Serena; Federspiel, Andrea; Slavova, Nedelina Bozhidarova; Wiest, Roland; Grunt, Sebastian; Steinlin, Maja and Everts, Regula

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1053-8119

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

24 Sep 2020 17:04

Last Modified:

25 Sep 2020 01:34

Publisher DOI:

10.1016/j.neuroimage.2020.117361

PubMed ID:

32919055

Uncontrolled Keywords:

MRI Thalamo-cortical functional connectivity rsfMRI subcortical subnuclei thalamus

BORIS DOI:

10.7892/boris.146655

URI:

https://boris.unibe.ch/id/eprint/146655

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