The role of slow wave sleep in the development of dementia and its potential for preventative interventions

Wunderlin, Marina; Züst, Marc Alain; Fehér, Daniel Kristoffer; Klöppel, Stefan; Nissen, Christoph (2020). The role of slow wave sleep in the development of dementia and its potential for preventative interventions (In Press). Psychiatry research: Neuroimaging, p. 111178. Elsevier 10.1016/j.pscychresns.2020.111178

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The increasing incidence rate of dementia underlines the necessity to identify early biomarkers of imminent cognitive decline. Recent findings suggest that cognitive decline and the pathophysiology of Alzheimer's disease are closely linked to disruptions in slow wave sleep (SWS) – the deepest sleep stage. SWS is essential for memory functions and displays a potentially causal and bidirectional link to the accumulation of amyloid beta deposition. Accordingly, improving SWS in older adults – especially when at risk for dementia – might slow down the rate of cognitive decline. Recent work suggests that SWS can be improved by specifically targeting the electrophysiological peaks of the slow waves with acoustic stimulation. In older adults, this approach is still fairly new and accompanied by challenges posed by the specific complexity of their sleep physiology, like lower amplitude slow waves and fragmented sleep architecture. We suggest an approach that tackles these issues and attempts to re-instate a sleep physiology that resembles a younger, healthier brain. With enough SWS of high quality, metabolic clearance and memory functions could benefit and help slowing the process of cognitive aging. Ultimately, acoustic stimulation to enhance SWS could serve as a cost-effective, non-invasive tool to combat cognitive decline.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Wunderlin, Marina; Züst, Marc; Fehér, Daniel Kristoffer; Klöppel, Stefan and Nissen, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Klink

Date Deposited:

24 Sep 2020 19:09

Last Modified:

25 Sep 2020 01:34

Publisher DOI:

10.1016/j.pscychresns.2020.111178

PubMed ID:

32919869

BORIS DOI:

10.7892/boris.146669

URI:

https://boris.unibe.ch/id/eprint/146669

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