Stimulating aged brains with transcranial direct current stimulation: Opportunities and challenges

Habich, Annegret; Fehér, Daniel Kristoffer; Antonenko, Daria; Boraxbekk, Carl-Johan; Flöel, Agnes; Nissen, Christoph; Siebner, Hartwig Roman; Thielscher, Axel; Klöppel, Stefan (2020). Stimulating aged brains with transcranial direct current stimulation: Opportunities and challenges. Psychiatry research: Neuroimaging, p. 111179. Elsevier 10.1016/j.pscychresns.2020.111179

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Ageing involves significant neurophysiological changes that are both systematic while at the same time exhibiting divergent trajectories across individuals. These changes underlie cognitive impairments in elderly while also affecting the response of aged brains to interventions like transcranial direct current stimulation (tDCS). While the cognitive benefits of tDCS are more variable in elderly, older adults also respond differently to stimulation protocols compared to young adults. The age-related neurophysiological changes influencing the responsiveness to tDCS remain to be addressed in-depth. We review and discuss the premise that, in comparison to the better calibrated brain networks present in young adults, aged systems perform further away from a homoeostatic set-point. We argue that this age-related neurophysiological deviation from the homoeostatic optimum extends the leeway for tDCS to modulate the aged brain. This promotes the potency of immediate tDCS effects to induce directional plastic changes towards the homoeostatic equilibrium despite the impaired plasticity induction in elderly. We also consider how age-related neurophysiological changes pose specific challenges for tDCS that necessitate proper adaptations of stimulation protocols. Appreciating the distinctive properties of aged brains and the accompanying adjustment of stimulation parameters can increase the potency and reliability of tDCS as a treatment avenue in older adults.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Habich, Annegret; Fehér, Daniel Kristoffer; Nissen, Christoph and Klöppel, Stefan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Klink

Date Deposited:

24 Sep 2020 19:16

Last Modified:

26 Sep 2020 06:43

Publisher DOI:

10.1016/j.pscychresns.2020.111179

BORIS DOI:

10.7892/boris.146670

URI:

https://boris.unibe.ch/id/eprint/146670

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