Use of platelet-rich fibrin for the treatment of gingival recessions: a systematic review and meta-analysis.

Miron, Richard J.; Moraschini, Vittorio; Del Fabbro, Massimo; Piattelli, Adriano; Fujioka-Kobayashi, Masako; Zhang, Yufeng; Saulacic, Nikola; Schaller, Benoit; Kawase, Tomoyuki; Cosgarea, Raluca; Jepsen, Soren; Tuttle, Delia; Bishara, Mark; Canullo, Luigi; Eliezer, Meizi; Stavropoulos, Andreas; Shirakata, Yoshinori; Stähli, Alexandra; Gruber, Reinhard; Lucaciu, Ondine; ... (2020). Use of platelet-rich fibrin for the treatment of gingival recessions: a systematic review and meta-analysis. Clinical oral investigations, 24(8), pp. 2543-2557. Springer-Verlag 10.1007/s00784-020-03400-7

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The aim of this systematic review and meta-analysis was to compare the use of platelet-rich fibrin (PRF) with other commonly utilized treatment modalities for root coverage procedures.


The eligibility criteria comprised randomized controlled trials (RCTs) comparing the performance of PRF with that of other modalities in the treatment of Miller class I or II (Cairo RT I) gingival recessions. Studies were classified into 5 categories as follows: (1) coronally advanced flap (CAF) alone vs CAF/PRF, (2) CAF/connective tissue graft (CAF/CTG) vs CAF/PRF, (3) CAF/enamel matrix derivative (CAF/EMD) vs CAF/PRF, (4) CAF/amnion membrane (CAF/AM) vs CAF/PRF, and (5) CAF/CTG vs CAF/CTG/PRF. Studies were evaluated for percentage of relative root coverage (rRC; primary outcome), clinical attachment level (CAL), keratinized mucosa width (KMW), and probing depth (PD) (secondary outcomes).


From 976 articles identified, 17 RCTs were included. The use of PRF statistically significantly increased rRC and CAL compared with CAF alone. No change in KMW or reduction in PD was reported. Compared with PRF, CTG resulted in statistically significantly better KMW and RC. No statistically significant differences were reported between the CAF/PRF and CAF/EMD groups or between the CAF/PRF and CAF/AM groups for any of the investigated parameters.


The use of CAF/PRF improved rRC and CAL compared with the use of CAF alone. While similar outcomes were observed between CAF/PRF and CAF/CTG for CAL and PD change, the latter group led to statistically significantly better outcomes in terms of rRC and KTW. In summary, the use of PRF in conjunction with CAF may represent a valid treatment modality for gingival recessions exhibiting adequate baseline KMW.


The data indicate that the use of PRF in conjunction with CAF statistically significantly improves rRC when compared with CAF alone but did not improve KMW. Therefore, in cases with limited baseline KMW, the use of CTG may be preferred over PRF.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Kobayashi, Masako; Saulacic, Nikola; Schaller, Benoît; Eliezer-Shatz, Meizi; Stähli, Alexandra Beatrice and Sculean, Anton


600 Technology > 610 Medicine & health








Caroline Dominique Zürcher

Date Deposited:

07 Oct 2020 17:06

Last Modified:

07 Oct 2020 17:15

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Gingival recession L-PRF Periodontal plastic surgery Platelet-rich fibrin




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