Recurrent Blood Pressure Rise after Treatment with Anti-vascular Endothelial Growth Factor Agents.

Wyssmüller, Iris; Schaal, Karen; Wolf, Sebastian; Zinkernagel, Martin (2020). Recurrent Blood Pressure Rise after Treatment with Anti-vascular Endothelial Growth Factor Agents. Klinische Monatsblätter für Augenheilkunde, 237(4), pp. 454-457. Thieme 10.1055/a-1081-1635

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BACKGROUND

It has previously been shown that the process of anti-vascular endothelial growth factor (VEGF) injections can lead to a significant increase of blood pressure. The aim of this study was to investigate whether this blood pressure increase was reproducible with repeated anti-VEGF injections.

PATIENTS AND METHODS

Patients with a systolic blood pressure of ≥ 180 mmHg during previous injections who were scheduled for further injections were asked to participate in this study. Systolic as well as diastolic blood pressure was measured before, during, and after the intravitreal injection process.

RESULTS

Thirty-nine patients (21 females, 18 males) with a mean age of 75 years (range 34 - 94 years) were included in this extension of the FEAR study. At first, clinical systolic blood pressure rose from an average of 157.3 ± 5.9 mmHg to 175 ± 6.7 mmHg at the time of the injection process (p < 0.01). Diastolic blood pressure rose from an average of 75.72 ± 4.2 mmHg to 84.44 ± 7.3 mmHg (p < 0.13) at the time of the injection process. Overall, the majority of the participants (56%, N = 22) had a systolic blood pressure of ≥ 180 mmHg.

CONCLUSIONS

Our results show that the blood pressure increase occurs persistently during the injection process in some patients. Repeated episodes of severe hypertension may predispose patients to cardiovascular events, especially those with concomitant cardiovascular risk factors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Schaal, Karen Beate; Wolf, Sebastian and Zinkernagel, Martin Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-3999

Publisher:

Thieme

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

07 Oct 2020 12:16

Last Modified:

07 Oct 2020 12:24

Publisher DOI:

10.1055/a-1081-1635

PubMed ID:

32092777

BORIS DOI:

10.7892/boris.146840

URI:

https://boris.unibe.ch/id/eprint/146840

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