Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging.

Kellner-Weldon, Frauke; Jossen, Marina; Breiding, Philipe S.; Grunder, Lorenz; Schankin, Christoph; Scutelnic, Adrian; Fischer, Urs; Muri, Raphaela; Pastore-Wapp, Manuela; Wiest, Roland; El-Koussy, Marwan (2021). Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging. Clinical neuroradiology, 31(3), pp. 581-588. Springer-Verlag 10.1007/s00062-020-00962-7

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PURPOSE

Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PFV) on SWI in the acute phase.

METHODS

Between 2011 and 2018 we evaluated symptoms and MR imaging of adult patients with acute MwA attacks (< 5 days after onset of symptoms). Abnormal imaging was visually scored in 12 ROIs on both hemispheres distributed on 3 slices. The score ranged from 0 to 3.

RESULTS

In all, 638 patients (436 female) mean age 37.39 years (18-89 ± 14.13) were included. Susceptibility weighted imaging was abnormal in 18.8% of patients. The inferior and posterior medial temporal lobe and the occipital lobe were most often affected. Susceptibility weighted imaging was more likely abnormal when MR was performed within 24 hours with an average around 5 hours after symptom onset. The side of aura symptoms and hemispheric imaging alteration in patients with abnormal SWI was highly significant (p < 0.001).

CONCLUSION

In the acute episode of MwA, SWI imaging can show a combination of increased deoxygenation. The results may indicate linking PFV to MwA.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

 Kellner-Weldon, Frauke, Breiding, Philipe Sebastian, Grunder, Lorenz Nicolas, Schankin, Christoph Josef, Scutelnic, Adrian, Fischer, Urs Martin, Muri, Raphaela, Pastore-Wapp, Manuela, Wiest, Roland Gerhard Rudi, El-Koussy, Marwan

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1869-1447

Publisher:

 Springer-Verlag

Language:

 English

Submitter:

 Martin Zbinden

Date Deposited:

 12 Oct 2020 07:40

Last Modified:

 02 Mar 2023 23:33

Publisher DOI:

 10.1007/s00062-020-00962-7

PubMed ID:

 33001228

Uncontrolled Keywords:

 Deoxygenated hemoglobin Imaging techniques Magnetic resonance imaging Migraine disorders Temporal lobe

BORIS DOI:

 10.7892/boris.146905

URI:

 https://boris.unibe.ch/id/eprint/146905

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