Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia.

Viher, Petra; Abdulkadir, Ahmed; Savadijev, Peter; Stegmayer, Katharina; Kubicki, Marek; Makris, Nikos; Karmacharya, Sarina; Federspiel, Andrea; Bohlhalter, Stephan; Vanbellingen, Tim; Müri, René; Wiest, Roland; Strik, Werner; Walther, Sebastian (2020). Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia. Cortex, 132, pp. 322-333. Elsevier 10.1016/j.cortex.2020.05.023

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Hand gestures are an integral part of social interactions and communication. Several imaging studies in healthy subjects and lesion studies in patients with apraxia suggest the praxis network for gesture production, involving mainly left inferior frontal, posterior parietal and temporal regions. However, little is known about the structural connectivity underlying gesture production. We recruited 41 healthy participants and 39 patients with schizophrenia. All participants performed a gesture production test, the Test of Upper Limb Apraxia, and underwent diffusion tensor imaging. We hypothesized that gesture production is associated with structural network connectivity as well as with tract integrity. We defined the praxis network as an undirected graph comprised of 13 bilateral regions of interest and derived measures of local and global structural connectivity and tract integrity from Finsler geometry. We found an association of gesture deficit with reduced global and local efficiency of the praxis network. Furthermore, reduced tract integrity, for example in the superior longitudinal fascicle, arcuate fascicle or corpus callosum were related to gesture deficits. Our findings contribute to the understanding of structural correlates of gesture production as they first present diffusion tensor imaging data in a combined sample of healthy subjects and a patient cohort with gestural deficits.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Viher, Petra; Abdulkadir, Ahmed; Stegmayer, Katharina Deborah Lena; Federspiel, Andrea; Bohlhalter, Stephan; Vanbellingen, Tim; Müri, René Martin; Wiest, Roland; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0010-9452

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

09 Oct 2020 17:07

Last Modified:

07 Jan 2021 15:10

Publisher DOI:

10.1016/j.cortex.2020.05.023

PubMed ID:

33011518

Uncontrolled Keywords:

Diffusion weighted MRI Gesture Nonverbal communication Structural connectivity

BORIS DOI:

10.7892/boris.146906

URI:

https://boris.unibe.ch/id/eprint/146906

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