Is APOE ε4 associated with cognitive performance in early MS?

Engel, Sinah; Graetz, Christiane; Salmen, Anke; Muthuraman, Muthuraman; Toenges, Gerrit; Ambrosius, Björn; Bayas, Antonios; Berthele, Achim; Heesen, Christoph; Klotz, Luisa; Kümpfel, Tania; Linker, Ralf A; Meuth, Sven G; Paul, Friedemann; Stangel, Martin; Tackenberg, Björn; Then Bergh, Florian; Tumani, Hayrettin; Weber, Frank; Wildemann, Brigitte; ... (2020). Is APOE ε4 associated with cognitive performance in early MS? Neurology: Neuroimmunology and Neuroinflammation, 7(4) Wolters Kluwer Health 10.1212/NXI.0000000000000728

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OBJECTIVE

To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).

METHODS

This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of the APOE carrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors.

RESULTS

APOE ε4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed for APOE ε4 heterozygosity or APOE ε2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed for APOE carrier status.

CONCLUSION

Along with parameters of a higher disease burden, APOE ε4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Salmen, Anke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2332-7812

Publisher:

Wolters Kluwer Health

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

30 Oct 2020 17:00

Last Modified:

30 Oct 2020 19:01

Publisher DOI:

10.1212/NXI.0000000000000728

PubMed ID:

32358224

BORIS DOI:

10.7892/boris.147187

URI:

https://boris.unibe.ch/id/eprint/147187

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