Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories.

Kaufmann, Marco; Salmen, Anke; Barin, Laura; Puhan, Milo Alan; Calabrese, Pasquale; Kamm, Philipp; Gobbi, Claudio; Kuhle, Jens; Manjaly, Zina-Mary; Ajdacic-Gross, Vladeta; Schafroth, Sandra; Bottignole, Britta; Ammann, Sabin; Zecca, Chiara; D'Souza, Marcus; Von Wyl, Viktor (2020). Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories. Multiple Sclerosis and Related Disorders, 42(102148), p. 102148. Elsevier 10.1016/j.msard.2020.102148

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BACKGROUND

Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.

METHODS

We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.

RESULTS

Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively.

CONCLUSIONS

Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Salmen, Anke and Kamm, Christian Philipp

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2211-0348

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

03 Nov 2020 15:58

Last Modified:

15 Nov 2020 02:44

Publisher DOI:

10.1016/j.msard.2020.102148

PubMed ID:

32371376

Uncontrolled Keywords:

EDSS Patient reported outcome Proxy measure Registries Self-report

BORIS DOI:

10.7892/boris.147188

URI:

https://boris.unibe.ch/id/eprint/147188

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