Molecular mechanisms and imaging of lymphatic metastasis.

Proulx, Steven T; Detmar, Michael (2013). Molecular mechanisms and imaging of lymphatic metastasis. Experimental cell research, 319(11), pp. 1611-1617. Elsevier 10.1016/j.yexcr.2013.03.009

Text 1-s2.0-S0014482713001171-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (709kB)

In many types of cancer, tumors metastasize through the lymphatic system to draining lymph nodes. These sentinel lymph nodes have gained increased attention as a prognostic indicator for the severity of the disease, leading to the sentinel lymph node mapping and biopsy procedure to be accepted as standard-of-care for breast cancer and melanoma. However, many limitations exist with this procedure resulting in high false negative rates. In this review we highlight the new advances in the understanding of the molecular mechanisms of lymphangiogenesis and tumor metastasis that may lead to improved strategies in the detection of the sentinel lymph nodes and therapeutic interventions to prevent further tumor spread. In addition, advances in imaging technology are allowing new approaches for anatomical mapping of lymphatic drainage patterns and molecular imaging strategies that may improve detection of metastatic tumor cells within sentinel lymph nodes.

Interest & Impact

Downloads

1 since deposited on 23 Oct 2020
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item