Molecular mechanisms and imaging of lymphatic metastasis.

Proulx, Steven T; Detmar, Michael (2013). Molecular mechanisms and imaging of lymphatic metastasis. Experimental cell research, 319(11), pp. 1611-1617. Elsevier 10.1016/j.yexcr.2013.03.009

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In many types of cancer, tumors metastasize through the lymphatic system to draining lymph nodes. These sentinel lymph nodes have gained increased attention as a prognostic indicator for the severity of the disease, leading to the sentinel lymph node mapping and biopsy procedure to be accepted as standard-of-care for breast cancer and melanoma. However, many limitations exist with this procedure resulting in high false negative rates. In this review we highlight the new advances in the understanding of the molecular mechanisms of lymphangiogenesis and tumor metastasis that may lead to improved strategies in the detection of the sentinel lymph nodes and therapeutic interventions to prevent further tumor spread. In addition, advances in imaging technology are allowing new approaches for anatomical mapping of lymphatic drainage patterns and molecular imaging strategies that may improve detection of metastatic tumor cells within sentinel lymph nodes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-4827

Publisher:

Elsevier

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

23 Oct 2020 10:39

Last Modified:

23 Oct 2020 10:48

Publisher DOI:

10.1016/j.yexcr.2013.03.009

PubMed ID:

23499738

Uncontrolled Keywords:

Imaging Lymphatic vessels Metastasis Tumor

BORIS DOI:

10.7892/boris.147278

URI:

https://boris.unibe.ch/id/eprint/147278

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