Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.

Blum, Katrin S; Proulx, Steven T; Luciani, Paola; Leroux, Jean-Christophe; Detmar, Michael (2013). Dynamics of lymphatic regeneration and flow patterns after lymph node dissection. Breast cancer research and treatment, 139(1), pp. 81-86. Springer 10.1007/s10549-013-2537-7

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Knowledge about the mechanisms of regeneration of the lymphatic vasculature after surgical trauma is essential for the development of strategies for the prevention and therapy of lymphedema. However, little is known about the alterations of lymphatic flow directly after surgical trauma. We investigated lymphatic function in mice using near-infrared imaging for a period of 4 weeks after surgeries that mimic sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND), by removal of the popliteal lymph node (LN) alone or together with the popliteal fat pad, respectively. SLNB-like surgery did not cause changes in lymphatic drainage in the majority of cases. In contrast, lymphatic drainage impairment shown by collecting vessel rupture, dermal backflow and rerouting of lymph flow via collateral vessels were observed after ALND-like surgery. All collateral vessels drained to the inguinal LN. These results indicate that less invasive surgery prevents lymphatic decompensation. They also reveal the development and maturation of collateral lymphatic vessels after extensive surgical trauma, which reroute the flow of lymph towards a different LN. These findings might be helpful for the development of strategies to prevent and/or treat post-surgical lymphedema.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-6806

Publisher:

Springer

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

23 Oct 2020 10:17

Last Modified:

23 Oct 2020 10:44

Publisher DOI:

10.1007/s10549-013-2537-7

PubMed ID:

23613202

BORIS DOI:

10.7892/boris.147281

URI:

https://boris.unibe.ch/id/eprint/147281

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