Cues for seizure timing.

Rao, Vikram R; Leguia, Marc G.; Tcheng, Thomas K; Baud, Maxime O. (2020). Cues for seizure timing. (In Press). Epilepsia Wiley-Blackwell 10.1111/epi.16611

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The cyclical organization of seizures in epilepsy has been described since antiquity. However, historical explanations for seizure cycles-based on celestial, hormonal, and environmental factors-have only recently become testable with the advent of chronic electroencephalography (cEEG) and modern statistical techniques. Here, factors purported over millennia to influence seizure timing are viewed through a contemporary lens. We discuss the emerging concept that seizures are organized over multiple timescales, each involving differential influences of external and endogenous rhythm generators. Leveraging large cEEG datasets and circular statistics appropriate for cyclical phenomena, we present new evidence for circadian (day-night), multidien (multi-day), and circannual (about-yearly) variation in seizure activity. Modulation of seizure timing by multiscale temporal variables has implications for diagnosis and therapy in clinical epilepsy. Uncovering the mechanistic basis for seizure cycles, particularly the factors that govern multidien periodicity, will be a major focus of future work.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Grau Leguia, Marc and Baud, Maxime

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0013-9580

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

05 Nov 2020 16:06

Last Modified:

05 Nov 2020 16:06

Publisher DOI:

10.1111/epi.16611

PubMed ID:

32738157

Uncontrolled Keywords:

chronobiology circadian circannual multidien seizure cycles zeitgeber

BORIS DOI:

10.7892/boris.147335

URI:

https://boris.unibe.ch/id/eprint/147335

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