Dissociation of visual extinction and neglect in the left hemisphere.

Beume, Lena-Alexandra; Rijntjes, Michel; Dressing, Andrea; Kaller, Christoph P; Hieber, Maren; Martin, Markus; Kirsch, Simon; Kümmerer, Dorothee; Urbach, Horst; Umarova, Roza M.; Weiller, Cornelius (2020). Dissociation of visual extinction and neglect in the left hemisphere. Cortex, 129, pp. 211-222. Elsevier 10.1016/j.cortex.2020.04.010

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Visual neglect and extinction are two distinct visuospatial attention deficits that frequently occur after right hemisphere cerebral stroke. However, their different lesion profiles remain a matter of debate. In the left hemisphere, a domain-general dual-loop model with distinct computational abilities onto which several cognitive functions may project, has been proposed: a dorsal stream for sensori-motor mapping in time and space and a ventral stream for comprehension and representation of concepts. We wondered whether such a distinction may apply to visual extinction and neglect in left hemisphere lesions. Of 165 prospectively studied patients with acute left hemispheric ischemic stroke with a single lesion on MRI, 122 had no visuospatial attention deficit, 10 had extinction, 31 neglect and 2 had both, visual extinction and neglect. Voxel-based-lesion-symptom mapping (VLSM, FDR<.05) showed a clear anatomical dissociation. Extinction occurred after damage to the parietal cortex (anterior bank of the intraparietal sulcus, inferior parietal lobe, and supramarginal gyrus), while visual neglect occurred after damage mainly to the temporal lobe (superior and middle temporal lobe, anterior temporal pole), inferior ventral premotor cortex, frontal operculum, angular gyrus, and insula. Direct comparison of both conditions linked extinction to intraparietal sulcus and supramarginal gyrus (FDR<.05). Thus, in the left hemisphere extinction seems to be related to dorsal stream lesions, whereas neglect maps more on the ventral stream. These data cannot be generalized to the right hemisphere. However, a domain-general point-of-view may stimulate discussion on visuospatial attention processing also in the right hemisphere.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Umarova, Roza

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0010-9452

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

10 Nov 2020 09:30

Last Modified:

10 Nov 2020 09:30

Publisher DOI:

10.1016/j.cortex.2020.04.010

PubMed ID:

32505793

Uncontrolled Keywords:

Cerebral stroke Dissociation Left hemisphere Visual extinction Visual neglect

BORIS DOI:

10.7892/boris.147358

URI:

https://boris.unibe.ch/id/eprint/147358

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