REM sleep stabilizes hypothalamic representation of feeding behavior.

Oesch, Lukas T.; Gazea, Mary; Gent, Thomas C.; Bandarabadi, Mojtaba; Gutierrez Herrera, Carolina; Adamantidis, Antoine R. (2020). REM sleep stabilizes hypothalamic representation of feeding behavior. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 117(32), pp. 19590-19598. National Academy of Sciences NAS 10.1073/pnas.1921909117

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During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Oesch, Lukas Till; Gazea, Mary; Gent, Thomas Clifford; Bandarabadi, Mojtaba; Gutierrez Herrera, Carolina and Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0027-8424

Publisher:

National Academy of Sciences NAS

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

13 Nov 2020 11:37

Last Modified:

13 Nov 2020 11:37

Publisher DOI:

10.1073/pnas.1921909117

PubMed ID:

32732431

Uncontrolled Keywords:

REM sleep calcium imaging feeding lateral hypothalamus optogenetics

BORIS DOI:

10.7892/boris.147377

URI:

https://boris.unibe.ch/id/eprint/147377

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