Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.

Yeh, Chien-Hung; Al-Fatly, Bassam; Kühn, Andrea A; Meidahl, Anders C; Tinkhauser, Gerd; Tan, Huiling; Brown, Peter (2020). Waveform changes with the evolution of beta bursts in the human subthalamic nucleus. Clinical neurophysiology, 131(9), pp. 2086-2099. Elsevier 10.1016/j.clinph.2020.05.035

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OBJECTIVE

Phasic bursts of beta band synchronisation have been linked to motor impairment in Parkinson's disease (PD). However, little is known about what terminates bursts.

METHODS

We used the Hilbert-Huang transform to investigate beta bursts in the local field potential recorded from the subthalamic nucleus in nine patients with PD on and off levodopa.

RESULTS

The sharpness of the beta waveform extrema fell as burst amplitude dropped. Conversely, an index of phase slips between waveform extrema, and the power of concurrent theta activity increased as burst amplitude fell. Theta activity was also increased on levodopa when beta bursts were attenuated. These phenomena were associated with reduction in coupling between beta phase and high gamma activity amplitude. We discuss how these findings may suggest that beta burst termination is associated with relative desynchronization of the beta drive, increase in competing theta activity and increased phase slips in the beta activity.

CONCLUSIONS

We characterise the dynamical nature of beta bursts, thereby permitting inferences about underlying activities and, in particular, about why bursts terminate.

SIGNIFICANCE

Understanding the dynamical nature of beta bursts may help point to interventions that can cause their termination and potentially treat motor impairment in PD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

10 Nov 2020 17:17

Last Modified:

10 Nov 2020 17:17

Publisher DOI:

10.1016/j.clinph.2020.05.035

PubMed ID:

32682236

Uncontrolled Keywords:

Basal ganglia Beta bursts Local field potentials Motor network Subthalamic nucleus

BORIS DOI:

10.7892/boris.147386

URI:

https://boris.unibe.ch/id/eprint/147386

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