Differences in morphology and visual function of myelin oligodendrocyte glycoprotein antibody and multiple sclerosis associated optic neuritis.

Vicini, Rino; Brügger, Dominik; Abegg, Mathias; Salmen, Anke; Grabe, Hilary Michelle (2021). Differences in morphology and visual function of myelin oligodendrocyte glycoprotein antibody and multiple sclerosis associated optic neuritis. Journal of neurology, 268(1), pp. 276-284. Springer-Medizin-Verlag 10.1007/s00415-020-10097-x

[img]
Preview
Text
Vicini, 2020_Differences in morphology and visual function.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

BACKGROUND

Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON).

OBJECTIVE

This study aimed to define morphological characteristics of MOG-ON, correlate these with clinical characteristics and compare them with multiple sclerosis associated ON (MS-ON) and healthy controls (CTRL).

METHODS

In a retrospective study, we included MOG-ON and MS-ON patients seen between 2011 and 2018 at the University Hospital Bern. Data from clinical examination, perimetry, and optical coherence tomography (OCT) were analyzed.

RESULTS

A total of 66 eyes of 43 patients were included; 22 MS-ON and 33 CTRL eyes were sex- and age-matched to 11 MOG-ON eyes. We found significantly worse visual acuity at nadir, but better recovery and thinner global peripapillary retinal nerve fiber layer thickness in MOG-ON patients compared to MS-ON patients. Both groups exhibited irregular thinning of the macular ganglion cell layer. Furthermore, the visual acuity and visual field parameters correlated to retinal layer thickness only in MOG-ON eyes.

CONCLUSION

In comparison to MS-ON, MOG-ON is associated with more prominent acute vision loss and more pronounced global thinning of the pRNFL. Both entities result in similar final visual acuity and atrophy of the macular ganglion cell layer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Vicini, Rino; Brügger, Dominik Marcel; Abegg, Mathias; Salmen, Anke and Grabe, Hilary Michelle

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-5354

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

10 Nov 2020 11:31

Last Modified:

14 Mar 2021 05:04

Publisher DOI:

10.1007/s00415-020-10097-x

PubMed ID:

32785840

Uncontrolled Keywords:

Ganglion cell layer MOG MS OCT Optic neuritis RNFL

BORIS DOI:

10.7892/boris.147389

URI:

https://boris.unibe.ch/id/eprint/147389

Actions (login required)

Edit item Edit item
Provide Feedback