Wasserman, Danielle; Bassetti, Claudio L. A.; Rosenzweig, Ivana (2020). Narcolepsy with resolution of cataplexy and persisting orexin deficiency. Journal of clinical sleep medicine, 16(8), pp. 1383-1386. American Academy of Sleep Medicine 10.5664/jcsm.8572
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Narcolepsy type 1 is a debilitating chronic neurological disorder, whose main symptoms of excessive daytime sleepiness and cataplexy may partially improve with time, but typically do not fully resolve. The irreversible loss of orexin neurons is considered to be the pivotal mechanistic link underlying the development of cataplectic attacks in narcolepsy type 1. Here we describe a case of untreated narcolepsy type 1with low cerebrospinal orexin levels (< 50 pg/mL), where cataplexy fully resolved in the first 5-6 years after disease onset, whereas excessive daytime sleepiness persisted.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1550-9389 |
Publisher: |
American Academy of Sleep Medicine |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
12 Nov 2020 16:27 |
Last Modified: |
02 Mar 2023 23:33 |
Publisher DOI: |
10.5664/jcsm.8572 |
PubMed ID: |
32406370 |
URI: |
https://boris.unibe.ch/id/eprint/147396 |
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