Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li, Dan; Gromov, Kirill; Proulx, Steven T; Xie, Chao; Li, Jie; Crane, Daniel P; Søballe, Kjeld; O'Keefe, Regis J; Awad, Hani A; Xing, Lianping; Schwarz, Edward M (2010). Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Annals of the New York Academy of Sciences, 1192(1), pp. 84-94. Wiley 10.1111/j.1749-6632.2009.05210.x

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The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln- and OPG-treated mice was associated with a significant (P < 0.05) increase in the incidence of high-grade infections during the establishment of OM. In contrast, the high-grade infections in TNFR:Fc-treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram(+) biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0077-8923

Publisher:

Wiley

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

27 Oct 2020 12:09

Last Modified:

30 Oct 2020 00:35

Publisher DOI:

10.1111/j.1749-6632.2009.05210.x

PubMed ID:

20392222

BORIS DOI:

10.7892/boris.147403

URI:

https://boris.unibe.ch/id/eprint/147403

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