A role for spindles in the onset of rapid eye movement sleep.

Bandarabadi, Mojtaba; Gutierrez Herrera, Carolina; Gent, Thomas C.; Bassetti, Claudio; Schindler, Kaspar; Adamantidis, Antoine R. (2020). A role for spindles in the onset of rapid eye movement sleep. Nature Communications, 11(1), p. 5247. Springer Nature 10.1038/s41467-020-19076-2

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Sleep spindle generation classically relies on an interplay between the thalamic reticular nucleus (TRN), thalamo-cortical (TC) relay cells and cortico-thalamic (CT) feedback during non-rapid eye movement (NREM) sleep. Spindles are hypothesized to stabilize sleep, gate sensory processing and consolidate memory. However, the contribution of non-sensory thalamic nuclei in spindle generation and the role of spindles in sleep-state regulation remain unclear. Using multisite thalamic and cortical LFP/unit recordings in freely behaving mice, we show that spike-field coupling within centromedial and anterodorsal (AD) thalamic nuclei is as strong as for TRN during detected spindles. We found that spindle rate significantly increases before the onset of rapid eye movement (REM) sleep, but not wakefulness. The latter observation is consistent with our finding that enhancing spontaneous activity of TRN cells or TRN-AD projections using optogenetics increase spindle rate and transitions to REM sleep. Together, our results extend the classical TRN-TC-CT spindle pathway to include non-sensory thalamic nuclei and implicate spindles in the onset of REM sleep.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bandarabadi, Mojtaba; Gutierrez Herrera, Carolina; Gent, Thomas Clifford; Bassetti, Claudio; Schindler, Kaspar Anton and Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Springer Nature

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

06 Nov 2020 12:14

Last Modified:

15 Nov 2020 02:44

Publisher DOI:

10.1038/s41467-020-19076-2

PubMed ID:

33067436

BORIS DOI:

10.7892/boris.147441

URI:

https://boris.unibe.ch/id/eprint/147441

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