Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.

Amstutz, Deborah; Paschen, Steffen; Lachenmayer, Martin Lenard; Maradan-Gachet, Marie Elise; Deuschl, Günther; Krack, Paul; Debove, Ines (2020). Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease. CNS & neurological disorders, drug targets, 19(8), pp. 611-617. Bentham Science Publishers 10.2174/1871527319666200720105553

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BACKGROUND

Impulse control disorders (ICDs) and related disorders are common side effects of dopaminergic treatment in Parkinson's disease (PD) and are associated with negative effects on mental and physical health, quality of life and interpersonal relationships. Current management options are limited, as a reduction of dopaminergic medication often leads to worsening of motor symptoms or dopamine agonist withdrawal syndrome.

OBJECTIVE

To investigate if ICDs improve, worsen, or remain stable after subthalamic deep brain stimulation (STN-DBS).

METHODS

We reviewed retrospective, prospective and randomized-controlled studies published between 2000 and 2019 examining the effect of STN-DBS on one or more ICDs. Number of participants, time of follow-up, methods used to measure ICDs, type of ICDs, the incidence of ICDs before STN-DBS, the incidence of improvement (remission or reduction) of ICDs after STN-DBS, the incidence of de novo ICDs or worsening of ICDs after STN-DBS, stimulation parameters, lead position, change in motor score and change in medication are reported for each study.

RESULTS AND CONCLUSION

Available studies suggest that ICDs improve after STN- DBS in most patients and that persisting new-onset ICDs induced by DBS are rare. However, more randomized-controlled studies are needed to confirm the findings and to further investigate the underlying mechanisms.

Interest & Impact

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