DAPT Score and the Impact of Ticagrelor Monotherapy During the Second Year After PCI.

Chichareon, Ply; Modolo, Rodrigo; Kawashima, Hideyuki; Takahashi, Kuniaki; Kogame, Norihiro; Chang, Chun-Chin; Tomaniak, Mariusz; Ono, Masafumi; Walsh, Simon; Suryapranata, Harry; Cotton, James; Koning, Rene; Akin, Ibrahim; Kukreja, Neville; Wykrzykowska, Joanna; Piek, Jan J; Garg, Scot; Hamm, Christian; Steg, Philippe Gabriel; Jüni, Peter; ... (2020). DAPT Score and the Impact of Ticagrelor Monotherapy During the Second Year After PCI. JACC. Cardiovascular Interventions, 13(5), pp. 634-646. Elsevier 10.1016/j.jcin.2019.12.018

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OBJECTIVES

This study assessed the ability of the dual-antiplatelet therapy (DAPT) score in stratifying ischemic and bleeding risk in a contemporary percutaneous coronary intervention (PCI) population.

BACKGROUND

The DAPT score is recommended by guidelines as a tool to stratify ischemic and bleeding risk. Its utility in contemporary PCI is unknown.

METHODS

The study studied patients in GLOBAL LEADERS (A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation) who were free of major ischemic and bleeding events and adhered to antiplatelet strategy during the first year after PCI. The primary ischemic endpoint was the composite of myocardial infarction or stent thrombosis. The primary bleeding endpoint was Bleeding Academic Research Consortium type 3 or 5. Outcomes from 12 to 24 months after PCI were compared according to the DAPT score.

RESULTS

Of 11,289 patients that were event-free after the first year, 6,882 and 4,407 patients had low (<2) and high (≥2) DAPT scores, respectively. Compared with a low DAPT score, patients with a high DAPT score had a higher rate of the composites of myocardial infarction or stent thrombosis (0.70% vs. 1.55%; p < 0.0001). The rate of Bleeding Academic Research Consortium type 3 or 5 bleeding was 0.54% and 0.30% in the low and high DAPT score groups, respectively (p = 0.058). The effect of ticagrelor versus aspirin monotherapy on primary ischemic and bleeding endpoints during the second year were no different among the 2 groups.

CONCLUSIONS

The DAPT score can stratify ischemic but not bleeding risk in a contemporary PCI population during the second year. The score did not provide additional value for selection of antiplatelet strategy beyond the first year.

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