Meta-Analysis of Bioprosthetic Valve Thrombosis after Transcatheter Aortic Valve Implantation.

Rheude, Tobias; Pellegrini, Costanza; Stortecky, Stefan; Marwan, Mohamed; Xhepa, Erion; Ammon, Fabian; Pilgrim, Thomas; Mayr, N Patrick; Husser, Oliver; Achenbach, Stephan; Windecker, Stephan; Cassese, Salvatore; Joner, Michael (2021). Meta-Analysis of Bioprosthetic Valve Thrombosis after Transcatheter Aortic Valve Implantation. American journal of cardiology, 138, pp. 92-99. Elsevier 10.1016/j.amjcard.2020.10.018

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Bioprosthetic valve thrombosis may complicate transcatheter aortic valve implantation (TAVI). This meta-analysis sought to evaluate the prevalence and clinical impact of subclinical leaflet thrombosis (SLT) and clinical valve thrombosis (CVT) after TAVI. We summarized diagnostic strategies, prevalence of SLT and/or CVT and estimated their impact on the risk of all-cause death and stroke. Twenty studies with 12,128 patients were included. The prevalence of SLT and CVT was 15.1% and 1.2%, respectively. The risk of all-cause death was not significantly different between patients with SLT (RR 0.77; p= 0.22) and CVT (RR 1.29; p= 0.68) compared to patients without. The risk of stroke was higher in patients with CVT (RR 7.51; p< 0.001) as compared to patients without, while patients with SLT showed no significant increase in the risk of stroke (RR 1.81; p= 0.17). Reduced left ventricular function was associated with increased prevalence, while oral anticoagulation was associated with reduced prevalence of bioprosthetic valve thrombosis. Bioprosthetic valve thrombosis is frequent after TAVI, but does not increase the risk of death. Clinical valve thrombosis is associated with a significantly increased risk of stroke. Future studies should focus on prevention and treatment of bioprosthetic valve thrombosis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Stortecky, Stefan, Pilgrim, Thomas, Windecker, Stephan


600 Technology > 610 Medicine & health








Nadia Biscozzo

Date Deposited:

04 Dec 2020 05:55

Last Modified:

05 Dec 2022 15:41

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Aortic stenosis Leaflet thrombosis TAVI Valve thrombosis




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