Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers

Fuster, Daniel G.; Morard, Gaétan; Schneider, Lisa; Mattmann, Cedric; Lüthi, David; Vogt, Bruno; Dhayat, Nasser A. (2020). Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers (In Press). Nephrology, dialysis, transplantation Oxford University Press 10.1093/ndt/gfaa360

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Background. Sex-specific differences in nephrolithiasis with respect to both distribution of prevalence and stone composition are widely described and may be influenced by sex hormones.
Methods. We conducted a cross-sectional analysis of the relationship between 24-hour urinary sex hormone metabolites measured by gas chromatography–mass spectrometry with urinary calcium, oxalate and citrate excretion in a cohort of 628 kidney stone formers from a tertiary care hospital in Switzerland, taking demographic characteristics, kidney function and dietary factors into account.
Results. We observed a positive association of urinary calcium with urinary testosterone and 17β-estradiol. Positive associations of urinary calcium with dehydroepiandrosterone, 5α-DH-testosterone, etiocholanolone, androsterone, and estriol were modified by net gastrointestinal alkali absorption or urinary sulfate excretion. As the only sex hormone, dehydroepiandrosterone was inversely associated with urinary oxalate excretion in adjusted analyses. Urinary citrate correlated positively with urinary testosterone. Associations of urinary citrate with urinary androsterone, 17β-estradiol and estriol were modified by urinary sulfate or sodium, or by sex.
Conclusions. Urinary androgens and estrogens are significantly associated with urinary calcium and citrate excretion, and associations are in part modified by diet. Our data furthermore reveal dehydroepiandrosterone as a novel factor associated with urinary oxalate excretion in humans.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Fuster, Daniel Guido; Vogt, Bruno and Dhayat, Nasser

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0931-0509

Publisher:

Oxford University Press

Language:

English

Submitter:

Nasser Dhayat

Date Deposited:

04 Jan 2021 08:25

Last Modified:

05 Jan 2021 01:32

Publisher DOI:

10.1093/ndt/gfaa360

PubMed ID:

33295624

Uncontrolled Keywords:

sex steroid hormones, nephrolithiasis, lithogenic risk factors, dietary factors

BORIS DOI:

10.48350/147608

URI:

https://boris.unibe.ch/id/eprint/147608

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