Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer.

Visini, Miranda; Giger, Roland; Shelan, Mohamed; Eliçin, Olgun; Anschuetz, Lukas (2021). Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer. The Laryngoscope, 131(5), E1543-E1549. Wiley 10.1002/lary.29186

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OBJECTIVES/HYPOTHESIS

Hypopharyngeal squamous cell carcinoma (SCC) is a rare but aggressive malignancy, with low survival rates and high incidence of tumor and treatment-related morbidity. This study aims to analyze the long-term oncologic and functional outcomes of a large cohort of patients and to determine prognostic factors.

STUDY DESIGN

Retrospective cohort study.

METHODS

The records of all patients diagnosed with hypopharyngeal SCC and treated with curative intent at our tertiary referral center were reviewed. Patient and initial disease characteristics, features, and complications of primary treatment, recurrence patterns, and corresponding treatments and the oncologic and functional long-term outcome were determined.

RESULTS

For a total of 179 patients, primary radiotherapy (RT) was the predominant treatment modality (78%), whereas 22% underwent primary surgery. The median, 2-year, and 5-year overall survival (OS) for the study cohort were 47 months, 64% and 43%. The median survival after first and second relapse was 7 and 6 months, respectively. The 2 and 5-year relapse-free survival (RFS) was 52% and 36%. The median RFS after first relapse and salvage treatment was 9 months. A nodal status of ≥cN2 (HR = 1.89, CI:1.21-3.05, P < .005) and any other primary tumor localization than pyriform sinus (HR = 1.60, CI: 1.04-2.42, P < .05) were identified as independent risk factors for shorter OS and RFS. Regarding functional outcome, the 2- and 5-year laryngectomy-free-survival was 55% and 37%, respectively.

CONCLUSIONS

In this large cohort with long-term follow-up, any other primary tumor localization than pyriform sinus and a nodal status of ≥cN2 were identified as risk factors for reduced OS and RFS.

LEVEL OF EVIDENCE

4 Laryngoscope, 2020.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Visini, Miranda Sarina Ramona; Giger, Roland; Shelan, Mohamed; Eliçin, Olgun and Anschütz, Lukas Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1531-4995

Publisher:

Wiley

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

03 Dec 2020 17:55

Last Modified:

22 Sep 2021 16:27

Publisher DOI:

10.1002/lary.29186

PubMed ID:

33098325

Uncontrolled Keywords:

Hypopharyngeal cancer feeding tube functional outcome oncologic outcome quality of life relapse tracheostomy

BORIS DOI:

10.7892/boris.147710

URI:

https://boris.unibe.ch/id/eprint/147710

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