Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

Hubbard, Jeffrey; Gent, Thomas C; Hoekstra, Marieke M B; Emmenegger, Yann; Mongrain, Valerie; Landolt, Hans-Peter; Adamantidis, Antoine R.; Franken, Paul (2020). Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep. Nature Communications, 11(1), p. 3130. Springer Nature 10.1038/s41467-020-16915-0

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Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS) EEG delta (δ-)power are widely used as proxy for a sleep homeostatic process. Here, we noted frequency increases in δ-waves in sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We identified two classes of δ-waves; one responding to sleep deprivation with high initial power and fast, discontinuous decay during recovery sleep (δ2) and another unrelated to time-spent-awake with slow, linear decay (δ1). Reanalysis of previously published datasets demonstrates that δ-band heterogeneity after sleep deprivation is also present in human subjects. Similar to sleep deprivation, silencing of centromedial thalamus neurons boosted subsequent δ2-waves, specifically. δ2-dynamics paralleled that of temperature, muscle tone, heart rate, and neuronal ON-/OFF-state lengths, all reverting to characteristic NREMS levels within the first recovery hour. Thus, prolonged waking seems to necessitate a physiological recalibration before typical NREMS can be reinstated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Springer Nature

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

17 Nov 2020 16:50

Last Modified:

22 Nov 2020 02:49

Publisher DOI:

10.1038/s41467-020-16915-0

PubMed ID:

32561733

BORIS DOI:

10.7892/boris.147742

URI:

https://boris.unibe.ch/id/eprint/147742

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