Gesture deficits and apraxia in schizophrenia.

Walther, Sebastian; Mittal, Vijay A; Stegmayer, Katharina Deborah Lena; Bohlhalter, Stephan (2020). Gesture deficits and apraxia in schizophrenia. Cortex, 133, pp. 65-75. Elsevier 10.1016/j.cortex.2020.09.017

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Aberrant performance of skilled action has long been noted in schizophrenia and relatedly, recent reports have demonstrated impaired use, performance, and perception of hand gestures in this group. Still, this deficit is not acknowledged as apraxia, which to the broader medical field, characterizes impairments in skilled actions. Understanding the relationship between apraxia and schizophrenia may shed an invaluable new perspective on disease mechanism, and highlight novel treatment opportunities as well. To examine this potential link, we reviewed the evidence for the types of praxis errors, associated psychopathology, and cerebral correlates of the praxis deficit in schizophrenia. Notably, the review indicated that gesture deficits are severe enough to be considered genuine apraxia in a substantial proportion of patients (about 25%). Further, other potential contributors (e.g., hypokinetic motor abnormalities, cognitive impairment) are indeed associated with gesture deficits in schizophrenia, but do not sufficiently explain the abnormality. Finally, patients with praxis deficits have altered brain structure and function including the left parieto-premotor praxis network and these neural correlates are specific to the praxis deficit. Therefore, we argue that the gestural disorder frequently observed in schizophrenia shares both the clinical and neurophysiological features of true apraxia, as in other neuropsychiatric disorders with impaired higher order motor control, such as Parkinson's disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian; Stegmayer, Katharina Deborah Lena and Bohlhalter, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0010-9452

Publisher:

Elsevier

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

03 Dec 2020 15:19

Last Modified:

13 Dec 2020 01:34

Publisher DOI:

10.1016/j.cortex.2020.09.017

PubMed ID:

33099076

Uncontrolled Keywords:

Motor abnormalities Non-verbal communication Praxis deficit Psychosis

BORIS DOI:

10.7892/boris.147766

URI:

https://boris.unibe.ch/id/eprint/147766

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