Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation.

Karnani, Mahesh M; Schöne, Cornelia; Bracey, Edward F; González, J Antonio; Viskaitis, Paulius; Li, Han-Tao; Adamantidis, Antoine Roger; Burdakov, Denis (2020). Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation. Progress in neurobiology, 187, p. 101771. Elsevier 10.1016/j.pneurobio.2020.101771

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Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in vivo. The necessity of these activity bursts for sensorimotor control and their roles in specific phases of movement are unknown. Here we show that temporally-restricted optosilencing of spontaneous or sensory-evoked HON bursts disrupts locomotion initiation, but does not affect ongoing locomotion. Conversely, HON optostimulation initiates locomotion with subsecond delays in a frequency-dependent manner. Using 2-photon volumetric imaging of activity of >300 HONs during sensory stimulation and self-initiated locomotion, we identify several locomotion-related HON subtypes, which distinctly predict the probability of imminent locomotion initiation, display distinct sensory responses, and are differentially modulated by food deprivation. By causally linking HON bursts to locomotion initiation, these findings reveal the sensorimotor importance of rapid spontaneous and evoked fluctuations in HON ensemble activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-5118

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

03 Nov 2020 17:16

Last Modified:

15 Nov 2020 02:45

Publisher DOI:

10.1016/j.pneurobio.2020.101771

PubMed ID:

32058043

Uncontrolled Keywords:

Ensemble imaging Hypothalamus Locomotion Sensorimotor processing orexin/hypocretin neurons

BORIS DOI:

10.7892/boris.147787

URI:

https://boris.unibe.ch/id/eprint/147787

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