Banholzer, Nicolas; Herzig, David; Piazza, Camillo; Álvarez-Martínez, Mario; Nakas, Christos T; Kosinski, Christophe; Feuerriegel, Stefan; Hovorka, Roman; Bally, Lia (2021). Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes, obesity & metabolism, 23(1), pp. 234-239. Wiley 10.1111/dom.14187
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Fully automated closed-loop insulin delivery may offer a novel way to manage diabetes in hospital. However, postprandial glycaemic control remains challenging. We aimed to assess the effect of nutritional intake on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully closed-loop insulin therapy. The effects of different meal types and macronutrient composition on sensor glucose time-in-target (TIT, 3.9-10.0 mmol/L) and mean sensor glucose were assessed with hierarchical linear models using a Bayesian estimation approach. TIT was lower and the mean sensor glucose slightly higher, after breakfast compared with lunch and dinner, whereas the insulin dose was higher. Across meals, when carbohydrates were replaced by fat, or to a lesser extent by protein, postprandial glucose control improved. For breakfast, a 3.9% improvement in TIT was observed when 10% of the energy from carbohydrates was replaced by fat. Improvements were slightly lower during lunch and dinner (3.2% and 3.4%) or when carbohydrates were replaced by protein (2.2 and 2.7%, respectively). We suggest that reducing carbohydrate at the expense of fat or protein, could further improve glucose control during fully closed-loop insulin therapy in hospital.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Herzig, David, Nakas, Christos T., Kosinski, Christophe, Bally, Lia Claudia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1463-1326 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Karin Balmer |
Date Deposited: |
09 Nov 2020 14:03 |
Last Modified: |
05 Dec 2022 15:41 |
Publisher DOI: |
10.1111/dom.14187 |
PubMed ID: |
32885596 |
Uncontrolled Keywords: |
glycaemic control insulin therapy type 2 diabetes |
BORIS DOI: |
10.7892/boris.147796 |
URI: |
https://boris.unibe.ch/id/eprint/147796 |
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