Effect of fully automated closed-loop insulin delivery using faster aspart versus standard aspart on gluco-regulatory hormones in type 2 diabetes.

Herzig, David; Studer, David; Nakas, Christos T; Kuenzli, Christina; Stauffer, Thomas P; Hovorka, Roman; Bally, Lia (2021). Effect of fully automated closed-loop insulin delivery using faster aspart versus standard aspart on gluco-regulatory hormones in type 2 diabetes. Diabetes, obesity & metabolism, 23(1), pp. 228-233. Wiley 10.1111/dom.14185

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We retrospectively assessed gluco-regulatory hormones over 10 h (including two meals) of fully automated closed-loop insulin delivery using faster (FA) versus standard insulin aspart (IAsp) in adults with type 2 diabetes [n = 15, age 59 ± 10 years, body mass index 34.5 ± 9.1 kg/m2 , glycated haemoglobin 7.7 ± 1.2% (60 ± 13 mmol/mol)]. Plasma concentration of human insulin, IAsp, C-peptide, glucagon, glucagon-like peptide 1, glucose-dependent insulinotropic peptide and peptide tyrosine tyrosine were measured every 15-30 min. Endogenous insulin secretion was calculated using C-peptide deconvolution and exposures to hormones were compared using their mean plasma concentrations. Ten-hour exposure of IAsp was higher with FA versus IAsp (P = .037) in line with the 10% higher insulin requirements to achieve similar glucose control. No significant difference was found for total insulin exposure and endogenous insulin secretion. Similarly, other gluco-regulatory hormones did not significantly differ. In conclusion, the faster pharmacokinetic profile and slightly higher aspart exposure of FA versus IAsp remained without significant effects on endogenous insulin secretion or other gluco-regulatory hormones. Further studies are warranted to explore the metabolic and endocrine effects of novel insulins with accelerated pharmacokinetic properties.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Herzig, David; Nakas, Christos T. and Bally, Lia Claudia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1463-1326

Publisher:

Wiley

Language:

English

Submitter:

Karin Balmer

Date Deposited:

09 Nov 2020 12:26

Last Modified:

16 Dec 2020 01:33

Publisher DOI:

10.1111/dom.14185

PubMed ID:

32902125

Uncontrolled Keywords:

incretin physiology insulin analogues insulin pump therapy insulin secretion type 2 diabetes

BORIS DOI:

10.7892/boris.147797

URI:

https://boris.unibe.ch/id/eprint/147797

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