Heritable arrhythmias associated with abnormal function of cardiac potassium channels.

Crotti, Lia; Odening, Katja E; Sanguinetti, Michael C (2020). Heritable arrhythmias associated with abnormal function of cardiac potassium channels. Cardiovascular research, 116(9), pp. 1542-1556. Oxford University Press 10.1093/cvr/cvaa068

Preview

Text Hereditable arrythmias associated with abnormal function of the potassium channels.pdf - Published Version Available under License Publisher holds Copyright. Download (961kB) | Preview

Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentrations of intracellular sodium, calcium, and ATP/ADP. Here, we review the diversity and functional roles of cardiac potassium channels under normal conditions and how heritable mutations in the genes encoding these channels can lead to distinct arrhythmias. We briefly review atrial fibrillation and J-wave syndromes. For long and short QT syndromes, we describe their genetic basis, clinical manifestation, risk stratification, traditional and novel therapeutic approaches, as well as insights into disease mechanisms provided by animal and cellular models.

Interest & Impact

Downloads

47 since deposited on 07 Dec 2020
41 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item