Active immunisation against GnRH as treatment for unilateral granulosa theca cell tumour in mares.

Behrendt, Daphne; Burger, Dominik; Gremmes, Steffen; Szunyog, Katja; Röthemeier, Selena; Sieme, Harald (2021). Active immunisation against GnRH as treatment for unilateral granulosa theca cell tumour in mares. Equine veterinary journal, 53(4), pp. 740-745. Wiley-Blackwell 10.1111/evj.13352

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BACKGROUND

Stallion-like or aggressive behaviour in mares affected by unilateral granulosa theca cell tumour (GTCT) is well-known, but use of a GnRH-vaccine as an alternative to surgical removal of the neoplastic ovary has not been investigated.

OBJECTIVES

To determine the effect of immunisation against GnRH on ovarian size, testosterone concentration, Anti-Müllerian hormone (AMH) concentration, and owner-reported behaviour in four mares affected by unilateral GTCT.

STUDY DESIGN

Retrospective case report.

METHODS

A presumptive diagnosis of GTCT was made in four mares based on clinical signs, behavioural changes, transrectal palpation, and ultrasonography. All mares were vaccinated twice with the GnRH-vaccine Improvac® on day 0 and on day 13-33. Further booster vaccinations were administered if aggressive behaviour recurred between days 15 and 498. Before and parallel to the vaccinations, serum levels of oestradiol, progesterone (P4), testosterone, and AMH were evaluated and transrectal ultrasonography was performed.

RESULTS

In all horses, analysis of serum levels of oestradiol, progesterone, testosterone, and AMH confirmed the clinical diagnosis of GTCT. Serum levels of testosterone dropped to baseline levels following the first two of three vaccination in all mares. In addition, AMH serum values decreased shortly after the second vaccination in three of four mares, and in one of the four mares returned to baseline levels. No further GTCT linked behaviour was reported by the owners and the affected ovaries diminished in size in all four cases.

MAIN LIMITATIONS

This report is a case series with a limited number of animals, no controls and no standardised immunisation protocol.

CONCLUSIONS

Repeated vaccinations with the GnRH-vaccine Improvac® mitigated owner-reported behavioural abnormalities and stopped tumour growth in four mares affected by unilateral GTCT over the entire observation period which extends to 7 years in one mare.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Burger, Dominik

Subjects:

600 Technology > 630 Agriculture

ISSN:

0425-1644

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Ursula Therese Horst

Date Deposited:

11 Nov 2020 11:13

Last Modified:

18 Jun 2021 01:31

Publisher DOI:

10.1111/evj.13352

PubMed ID:

32924167

Uncontrolled Keywords:

GnRH-vaccine granulosa theca cell tumour horse stallion-like behaviour

BORIS DOI:

10.7892/boris.147863

URI:

https://boris.unibe.ch/id/eprint/147863

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