Co-occurrence of malignant neoplasm and Hyperostosis Frontalis Interna in an Iron Age individual from Münsingen-Rain (Switzerland): A multi-diagnostic study

Laffranchi, Zita; Milella, Marco; Lombardo, Paolo; Langer, Rupert; Lösch, Sandra (2020). Co-occurrence of malignant neoplasm and Hyperostosis Frontalis Interna in an Iron Age individual from Münsingen-Rain (Switzerland): A multi-diagnostic study. International journal of paleopathology, 32, pp. 1-8. Elsevier 10.1016/j.ijpp.2020.10.008

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Objective: To re-analyze one of the oldest cases of malignant bone neoplasm with different analytical techniques. Material: The available skeletal remains of grave 138 (G138) from the Iron Age necropolis of Münsingen-Rain (Switzerland, 420–240 BC).
Methods: The bones are analyzed by means of morphological, radiographic, histological, and biogeochemical methods.
Results: The individual, a male aged between 35–50 years old, presents morphologically and radiographically a previously described coral-like bone neoformation on the proximal left humerus. The new analyses highlight previously undocumented coarse bone proliferation on the left scapula and lobular apposition on the endocranial surface of the frontal bone. The histological analysis of the humerus shows a ‘lace-like’ pattern of osteoid deposition without lamellation.
Conclusions: Our data support a diagnosis of osteoblastic malignant neoplasm, probably an osteosarcoma or, more likely, a dedifferentiated chondrosarcoma for the humerus and scapula, and of hyperostosis frontalis interna on the frontal. The co-presence of a malignant neoplasm and hyperostosis frontalis interna may be related to a hormonal imbalance, a possibility also suggested by atypical funerary treatment.
Significance: This study confirms G138 as one of the oldest cases of malignant bone neoplasm, adds new paleopathological data on this individual, and demonstrates the advantages of a multidisciplinary approach.
Limitations: The discussion of the pathological changes is limited by the representation and preservation of the skeletal elements. Suggestion for Future Research: Biomolecular and protein biomarkers analyses may help to refine the diagnostic conclusions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Anthropology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Milella, Marco; Lombardo, Paolo; Langer, Rupert and Lösch, Sandra

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology
900 History > 930 History of ancient world (to ca. 499)

ISSN:

1879-9817

Publisher:

Elsevier

Funders:

[42] Schweizerischer Nationalfonds

Language:

English

Submitter:

Sandra Lösch

Date Deposited:

12 Nov 2020 12:12

Last Modified:

15 Nov 2020 02:45

Publisher DOI:

10.1016/j.ijpp.2020.10.008

Uncontrolled Keywords:

Osteosarcoma; Chondrosarcoma; Hormonal imbalance; Late iron age; Histology; Radiolographic imaging

BORIS DOI:

10.7892/boris.147881

URI:

https://boris.unibe.ch/id/eprint/147881

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