Hypomagnesemia-Induced Cerebellar Syndrome-A Distinct Disease Entity? Case Report and Literature Review.

Kamm, Christian P.; Nyffeler, Thomas; Henzen, Christoph; Fischli, Stefan (2020). Hypomagnesemia-Induced Cerebellar Syndrome-A Distinct Disease Entity? Case Report and Literature Review. Frontiers in neurology, 11(968), p. 968. Frontiers Media S.A. 10.3389/fneur.2020.00968

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Clinical consequences of hypomagnesemia are manifold and include various neurological syndromes up to life-threatening conditions. Despite its importance, magnesium is generally not routinely determined leading to an under-recognition of hypomagnesemia-related disorders. In the past years, there are growing numbers of reports of hypomagnesemia-induced cerebellar syndromes (HiCS) with corresponding cerebellar edema, which might be a distinct disease entity. To provide further insights into HiCS, we describe a patient with HiCS and performed a literature review on cerebellar syndromes due to severe hypomagnesemia with regard to the clinical, MRI, and laboratory findings. We identified 17 cases, so including our case, 18 cases contribute to this review. Summarized, HiCS seems to be a distinct disease entity because of the remarkable similarities of clinical, MRI, and laboratory features. It should be diagnosed and treated early to avoid recurrent disease courses, residual symptoms, and potentially life-threatening conditions such as seizures. Physicians must be alert to HiCS as magnesium is usually not part of the routine electrolyte panel.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kamm, Christian Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-2295

Publisher:

Frontiers Media S.A.

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

20 Nov 2020 09:20

Last Modified:

09 Mar 2021 23:50

Publisher DOI:

10.3389/fneur.2020.00968

PubMed ID:

33013642

Uncontrolled Keywords:

MRI ataxia cerebellar syndrome hypomagnesemia literature review oedema recurrent disease

BORIS DOI:

10.7892/boris.147917

URI:

https://boris.unibe.ch/id/eprint/147917

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