Vaccination against Allergy: A Paradigm Shift?

Bachmann, Martin F.; Mohsen, Mona O.; Kramer, Matthias F; Heath, Matthew D (2020). Vaccination against Allergy: A Paradigm Shift? Trends in molecular medicine, 26(4), pp. 357-368. Cell Press 10.1016/j.molmed.2020.01.007

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Since the discovery that IgE antibodies mediate allergy, decades of research have unraveled complex mechanisms associated with conventional immunotherapy and the vital protagonists that shape 'immune tolerance' to allergens. Debate exists on what should constitute the dominant effector mechanism in driving rational drug designs for next-generation immunotherapies. As vaccine technology continues to advance, the development of novel vaccines in this area of continued medical need might stand on a threshold of breakthrough inspired by experiments by Dunbar on the passive vaccination of allergic animals more than 100 years ago. In this opinion article, we discuss both novel insights into IgG antibodies as the principle effector modality induced by specific immunotherapy and advances in antigen-carrier design that may catapult allergy treatment into our modern world.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Bachmann, Martin and Mohsen, Mona Omar Mahmoud

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-4914

Publisher:

Cell Press

Language:

English

Submitter:

Lee-Anne Brand

Date Deposited:

07 Dec 2020 09:36

Last Modified:

12 Mar 2021 08:41

Publisher DOI:

10.1016/j.molmed.2020.01.007

PubMed ID:

32277930

Uncontrolled Keywords:

SIT VLP allergy vaccination

BORIS DOI:

10.7892/boris.147938

URI:

https://boris.unibe.ch/id/eprint/147938

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