The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".

Mohsen, Mona O.; Augusto, Gilles; Bachmann, Martin F. (2020). The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics". Immunological reviews, 296(1), pp. 155-168. Wiley-Blackwell 10.1111/imr.12863

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Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus-like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can easily reach lymphoid organs in intact form for optimal activation of B and T cells. Adjusting size and zeta potential may allow investigators to further fine-tune delivery to lymphoid organs. An additional way to alter vaccine transfer to lymph nodes and spleen may be the formulation with micron-sized adjuvants that creates a local depot and results in a slow release of antigen and adjuvant. Ideally, the adjuvant in addition stimulates the innate immune system. The dynamics of the immune response may be further enhanced by inclusion of Toll-like receptor ligands, which many VLPs naturally package. Hence, considering the 3Ds in vaccine development may allow for enhancement of their attributes to tackle complex diseases, not usually amenable to conventional vaccine strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Mohsen, Mona Omar Mahmoud; Sousa Augusto, Gilles Anderson and Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-2896

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Lee-Anne Brand

Date Deposited:

07 Dec 2020 12:08

Last Modified:

07 Dec 2020 12:08

Publisher DOI:

10.1111/imr.12863

PubMed ID:

32472710

Uncontrolled Keywords:

delivery design dynamics vaccine virus-like particles

BORIS DOI:

10.7892/boris.147994

URI:

https://boris.unibe.ch/id/eprint/147994

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