Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners.

Thoms, Franziska; Haas, Stefanie; Erhart, Aline; Nett, Claudia S; Rüfenacht, Silvia; Graf, Nicole; Strods, Arnis; Patil, Gauravraj; Leenadevi, Thonur; Fontaine, Michael C; Toon, Lindsey A; Jennings, Gary T; Senti, Gabriela; Kündig, Thomas M; Bachmann, Martin F. (2020). Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners. Viruses, 12(3) Molecular Diversity Preservation International MDPI 10.3390/v12030288

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An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCatTM), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutralizing antibodies against the allergen Fel d 1, which reduces the level of reactive allergen, thus lowering the symptoms or even preventing allergic reactions in humans. The combined methodological field study included ten cat-allergic participants who lived together with their cats (n = 13), that were immunized with Fel-CuMV. The aim was to determine methods for measuring a change in allergic symptoms. A home-based provocation test (petting time and organ specific symptom score (OSSS)) and a general weekly (or monthly) symptom score (G(W)SS) were used to assess changes in allergic symptoms. The petting time until a pre-defined level of allergic symptoms was reached increased already early after vaccination of the cats and was apparent over the course of the study. In addition, the OSSS after provocation and G(W)SS recorded a persistent reduction in symptoms over the study period and could serve for long-term assessment. Hence, the immunization of cats with HypoCatTM (Fel-CuMV) may have a positive impact on the cat allergy of the owner, and changes could be assessed by the provocation test as well as G(W)SS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Lee-Anne Brand

Date Deposited:

07 Dec 2020 12:12

Last Modified:

07 Dec 2020 12:12

Publisher DOI:

10.3390/v12030288

PubMed ID:

32155887

Uncontrolled Keywords:

Fel d 1 HypoCat™ cat allergy vaccination virus-like particle

BORIS DOI:

10.7892/boris.147996

URI:

https://boris.unibe.ch/id/eprint/147996

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