Animal Models in Microbeam Radiation Therapy: A Scoping Review

Fernandez-Palomo, Cristian; Fazzari, Jennifer; Trappetti, Verdiana; Smyth, Lloyd; Janka, Heidrun; Laissue, Jean; Djonov, Valentin Georgiev (2020). Animal Models in Microbeam Radiation Therapy: A Scoping Review. Cancers, 12(3) MDPI AG 10.3390/cancers12030527

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Background: Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres. Objective: This scoping review was conducted to map the available evidence and provide a comprehensive overview of the similarities, differences, and outcomes of all experiments that have employed animal models in MRT. Methods: We considered articles that employed animal models for the purpose of studying the effects of MRT. We searched in seven databases for published and unpublished literature. Two independent reviewers screened citations for inclusion. Data extraction was done by three reviewers. Results: After screening 5688 citations and 159 full-text papers, 95 articles were included, of which 72 were experimental articles. Here we present the animal models and pre-clinical radiation parameters employed in the existing MRT literature according to their use in cancer treatment, non-neoplastic diseases, or normal tissue studies. Conclusions: The study of MRT is concentrated in brain-related diseases performed mostly in rat models. An appropriate comparison between MRT and conventional radiotherapy (instead of synchrotron broad beam) is needed. Recommendations are provided for future studies involving MRT

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Fernandez Palomo, Cristian Gabriel; Fazzari, Jennifer Michelina; Trappetti, Verdiana; Janka, Heidrun Ilonka; Laissue, Jean and Djonov, Valentin Georgiev

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

07 Dec 2020 14:49

Last Modified:

17 Dec 2020 14:47

Publisher DOI:

10.3390/cancers12030527

Related URLs:

PubMed ID:

32106397

BORIS DOI:

10.7892/boris.148111

URI:

https://boris.unibe.ch/id/eprint/148111

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