Embryo survival in the oviduct not significantly influenced by major histocompatibility complex social signaling in the horse.

Jeannerat, E.; Marti, E.; Thomas, S; Herrera, C.; Sieme, H.; Wedekind, C.; Burger, D. (2020). Embryo survival in the oviduct not significantly influenced by major histocompatibility complex social signaling in the horse. Scientific reports, 10(1), p. 1056. Springer Nature 10.1038/s41598-020-58056-w

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The major histocompatibility complex (MHC) influences sexual selection in various vertebrates. Recently, MHC-linked social signaling was also shown to influence female fertility in horses (Equus caballus) diagnosed 17 days after fertilization. However, it remained unclear at which stage the pregnancy was terminated. Here we test if MHC-linked cryptic female choice in horses happens during the first days of pregnancy, i.e., until shortly after embryonic entrance into the uterus and before fixation in the endometrium. We exposed estrous mares to one of several unrelated stallions, instrumentally inseminated them with semen of another stallion, and flushed the uterus 8 days later to test for the presence of embryos. In total 68 embryos could be collected from 97 experimental trials. This success rate of 70.1% was significantly different from the mean pregnancy rate of 45.7% observed 17 days after fertilization using the same experimental protocol but without embryo flushing. Embryo recovery rate was not significantly dependent on whether the mares had been socially exposed to an MHC-dissimilar or an MHC-similar stallion. These observations suggest that MHC-linked maternal strategies affect embryo survival mainly (or only) during the time of fixation in the uterus.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Marti, Eliane Isabelle and Burger, Dominik

Subjects:

600 Technology > 630 Agriculture

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Ursula Therese Horst

Date Deposited:

13 Nov 2020 14:51

Last Modified:

28 Apr 2021 12:05

Publisher DOI:

10.1038/s41598-020-58056-w

PubMed ID:

31974438

BORIS DOI:

10.7892/boris.148129

URI:

https://boris.unibe.ch/id/eprint/148129

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