Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical.

Boyer-Diaz, Zoe; Morata, Paloma; Aristu-Zabalza, Peio; Gibert-Ramos, Albert; Bosch, Jaime; Gracia-Sancho, Jordi (2020). Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical. Nutrients, 12(9) Molecular Diversity Preservation International MDPI 10.3390/nu12092627

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Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Bosch, Jaime and Gracia Sancho, Jorge Sergio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6643

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

11 Dec 2020 11:35

Last Modified:

25 May 2021 16:59

Publisher DOI:

10.3390/nu12092627

PubMed ID:

32872239

Uncontrolled Keywords:

TG-DHA cirrhosis inflammation liver fibrosis omega-3 oxidative stress

BORIS DOI:

10.7892/boris.148190

URI:

https://boris.unibe.ch/id/eprint/148190

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