Drug-Coated Balloon Treatment in Symptomatic Intracranial High Grade Stenosis : A Retrospective Study of 33 Patients.

Remonda, Luca; Diepers, Michael; Berberat, Jatta; Kahles, Timo; Anon, Javier; Nedeltchev, Krassen; Gruber, Philipp (2021). Drug-Coated Balloon Treatment in Symptomatic Intracranial High Grade Stenosis : A Retrospective Study of 33 Patients. Clinical neuroradiology, 31(1), pp. 45-49. Springer-Verlag 10.1007/s00062-020-00936-9

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PURPOSE

Endovascular therapy (EVT) represents an alternative treatment modality for symptomatic intracranial high-grade atherosclerotic stenosis (sICAS); however, periprocedural complication rates as well as midterm restenosis rates represent relevant limitations of EVT. Drug-coated balloon percutaneous transluminal angioplasty (DCB-PTA) may overcome some of these shortcomings. The aim of this study was to assess feasibility and safety as well as the stroke recurrence rate in 33 patients.

METHODS

A retrospective, monocentric cohort study of sICAS patients treated with DCB-PTA. Outcome measures were the periprocedural intracranial complication rate, the recurrent stroke rate and mortality during follow-up.

RESULTS

This cohort study included 33 patients with 35 sICAS treated with DCB-PTA. The median age was 72 years (interquartile range, IQR 66-77 years); median clinical and mean radiological follow-up time was 9 months (IQR 3-22 months). Median preprocedural degree of stenosis (WASID) was 80% (IQR 73-80%) and median postprocedural residual stenosis degree (WASID) was 50% (IQR 33-60%). Intracranial periprocedural complications occurred in 2 (6%) patients. The overall restenosis rate was 15% (n = 5). In four patients a symptomatic ischemic re-event occurred within 7 months after the initial treatment. None of the patients died.

CONCLUSION

This DCB-PTA cohort study showed a relatively low intracranial complication rate of 6% with a symptomatic recurrence rate of 12%. Larger trials are needed to validate these promising observations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Nedeltchev, Krassen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1869-1447

Publisher:

Springer-Verlag

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

26 Nov 2020 15:49

Last Modified:

24 Mar 2021 01:32

Publisher DOI:

10.1007/s00062-020-00936-9

PubMed ID:

32691077

Uncontrolled Keywords:

Drug-coated balloon (DCB) Intracranial atherosclerotic disease (ICAD) Intracranial stenosis Ischemic stroke Percutaneous transluminal angioplasty (PTA)

BORIS DOI:

10.7892/boris.148221

URI:

https://boris.unibe.ch/id/eprint/148221

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